KMID : 0361020090520050426
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Korean Journal of Otolaryngology - Head and Neck Surgery 2009 Volume.52 No. 5 p.426 ~ p.430
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Usefulness of Intraoperative Parathyroid Hormone Assay in Minimally Invasive Surgery
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Lee Ja-Hyun
Chung Sung-Min Kim Han-Su Moon Kyung-Ray Kim Hyun-Ji
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Abstract
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Background and Objectives£ºIntraoperative parathyroid hormone (PTH) assay has been proposed as an effective tool in minimally invasive parathyroidectomy. We evaluated its usefulness during minimally invasive parathyroidectomy.
Subjects and Method£ºTen patients (female 6, male 4) of primary hyperparathyroidism (8 single diseases, 2 multiple diseases) were analyzed retrospectively. We used computed tomography (CT) and 99mTc-Sestamibi (MIBI) scan for localization of parathyroid lesions preoperatively, and frozen biopsy and PTH assay at 10 (T-10), 20 (T-20) minutes after excision intraoperatively. We also compared the diagnostic sensitivity of CT and MIBI scan and intraoperative PTH.
Results£ºAll patients were treated successfully and in single disease group, diagnostic sensitivity of CT, MIBI scan were 75% and 87.5%, and that of T-10 was 75% and T-20 was 100%. In multiple disease group, diagnostic sensitivity of CT, MIBI scan were 75%, 87.5%, and that of PTH was 80%.
Conclusion£ºIntraoperative PTH assay improves cure rate in minimally invasive parathyroidectomy. It allowed intraoperative recognition of missed parathyroid lesions by preoperative imaging study.
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KEYWORD
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Parathyroid, Intraoperative parathyroid hormone
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